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院長あいさつ

院長あいさつ

院長・医師・医学博士 桑原大志

皆様、こんにちは。 不整脈専門医の桑原大志と申します。
当院は、不整脈診療に特化した循環器内科医療施設です。
私は20年以上にわたり不整脈専門医として診療を続けてまいりました。

当院をオープンするにあたり、不整脈診療にふさわしい環境づくりからはじめました。徹底的に電気的環境を整備し、電気ノイズを極限まで排除した手術室、高画質で低被ばくな検査機器など取り揃え、不整脈診療にふさわしい環境づくりをしました。

患者さんお一人おひとりの症状の原因を明らかにして、薬物治療、アブレーション治療、ペースメーカー治療など幅広い選択肢から、最適な治療を選択できます。
不整脈の原因は、加齢、高血圧、心臓病、飲酒のほか、睡眠時無呼吸症候群や喫煙などが挙げられます。当院では、確かな診断を行うために、失神、睡眠時無呼吸症候群、喫煙などの関連外来も設けています。

軽症、重症にかかわらず、すべての不整脈が診療対象です。また、当院で手術をした患者さんは、術後も24時間体制365日、診療できるような体制をとっています。不整脈で気になることがあればどうぞお気軽にご相談ください。

略歴

1991年(H3)愛媛大学医学部卒業後第2内科
1992年(H4)愛媛県立中央病院
1993年(H5)愛媛大学医学部付属病院
1994年(H6)愛媛大学医学部大学院
1998年(H10)同大学院卒業、医学部博士号取得
1998年(H10)愛媛県立新居浜病院
2002年(H14)国立循環器病センター
2004年(H16)横須賀共済病院 循環器センター
2015年(H27)横須賀共済病院 循環器センター副部長
2016年(H28)東京ハートリズムクリニック 開院

資格

  • 日本不整脈心電学会認定 不整脈専門医
  • 日本循環器学会認定 循環器専門医
  • 日本内科学会 認定内科医
  • 日本不整脈心電学会評議委員
  • 植え込み型除細動器(ICD)
    ペーシングによる心不全治療(CRT)認定医

症例数(2003年〜2016年6月 横須賀共済病院にて)

  • カテーテルアブレーション治療 3,000件以上
  • ペースメーカー植え込み200件以上
  • 発作性心房細動患者根治率 90〜95%
  • 慢性心房細動患者根治率 80〜90%

出版

発作ゼロ・再発ゼロをめざす「心房細動」治療
幻冬舎 (2016年8月)
Amazonランキング 売れ筋ランキング 書籍総合
心臓の医学部門 第1位(9/20~9/23調べ)

カレントテラピー

カレントテラピー 2016年2月号
特集 カテーテルアブレーションの適応と可能性 ―進化するテクノロジーとその活用―
ライフメディコム(2016年2月)

カテーテルアブレーション

格段にうまくいく カテーテルアブレーションの基本とコツ
~エキスパートが教える安全・確実な手技と合併症対策~
羊土社 (2015年4月)

エキスパートが本音で明かす

エキスパートが本音で明かす
不整脈診療の極意
南山堂(2015年5月)

不整脈診療

不整脈診療クリニカルクエスチョン200
診断と治療社(2015年4月)

不整脈概論

不整脈概論
~専門医になるためのエッセンシャルブック~
羊土社 (2015年4月)

心房細動カテーテルアブレーション

心房細動カテーテルアブレーション
~心房細動カテーテルアブレーションを行う前の心構えから実手技,トラブルシューティング,薬剤との関わり方,インフォームドコンセントを網羅したすべてがわかる必読書~
メジカルビュー社(2013年3月)

パーフェクトガイド

症例で学ぶ 循環器診療パーフェクトガイド
中山書店(2011年4月)

週刊日本医事新報 2013年10月特集号
二人三脚 不整脈診療
日本医事新報社

トラブルシューティング

不整脈診療のトラブルシューティング
~65のシークレット~
南江堂(2011年9月)

EBM

EBM循環器疾患の治療2012-2013
中外医学社(2012年4月)

medicina
2013年12月号 (通常号) ( Vol.50 No.13)
特集 不整脈の診断と治療-ポイントをおさえよう

呼吸と循環

呼吸と循環
2014年03月号 (通常号) ( Vol.62 No.3)
特集 最新の心房細動治療戦略-長期持続性心房細動に対するアブレーション
医学書院

英語論文

  1. Kuwahara T, Abe M, Yamaki M, Fujieda H, Abe Y, Hashimoto K, Ishiba M, Sakai H, Hishikari K, Takigawa M, Okubo K, Takagi K, Tanaka Y, Nakajima J, Takahashi A. Apixaban versus Warfarin for the Prevention of Periprocedural Cerebral Thromboembolism in Atrial Fibrillation Ablation: Multicenter Prospective Randomized Study. J Cardiovasc Electrophysiol. 2016; in press
  2. Kuwahara T. Intracardiac Echocardiography in Catheter Ablation for Atrial Fibrillation: It Is Better to See What You Are Doing? JAFIB. 2015 [cited 2015 Aug 11];7.
  3. Kuwahara T, Takahashi A, Takahashi Y, Okubo K, Takagi K, Fujino T, Kusa S, Takigawa M, Watari Y, Yamao K, Nakashima E, Kawaguchi N, Hikita H, Sato A, Aonuma K. Incidences of esophageal injury during esophageal temperature monitoring: a comparative study of a multi-thermocouple temperature probe and a deflectable temperature probe in atrial fibrillation ablation. J Interv Card Electrophysiol Int J Arrhythm Pacing. 2014;39:251–257.
  4. Kuwahara T, Takahashi A, Okubo K, Takagi K, Yamao K, Nakashima E, Kawaguchi N, Takigawa M, Watari Y, Sugiyama T, Handa K, Kimura S, Hikita H, Sato A, Aonuma K. Oesophageal cooling with ice water does not reduce the incidence of oesophageal lesions complicating catheter ablation of atrial fibrillation: randomized controlled study. Europace. 2014;16:834–839.
  5. Kuwahara T, Takahashi A, Takahashi Y, Kobori A, Miyazaki S, Takei A, Fujino T, Okubo K, Takagi K, Fujii A, Takigawa M, Watari Y, Hikita H, Sato A, Aonuma K. Prevention of periprocedural ischemic stroke and management of hemorrhagic complications in atrial fibrillation ablation under continuous warfarin administration. J Cardiovasc Electrophysiol. 2013;24:510–515.
  6. Kuwahara T, Takahashi A, Takahashi Y, Kobori A, Miyazaki S, Takei A, Fujino T, Okubo K, Takagi K, Fujii A, Takigawa M, Watari Y, Hikita H, Sato A, Aonuma K. Clinical Characteristics and Management of Periesophageal Vagal Nerve Injury Complicating Left Atrial Ablation of Atrial Fibrillation: Lessons from Eleven Cases. J Cardiovasc Electrophysiol. 2013; 24:847-851.
  7. Kuwahara T, Takahashi A. Periesophageal vagal nerve injury complicating atrial fibrillation ablation. Circ J. 2013;77:1984–1985.
  8. Kuwahara T, Takahashi A, Takahashi Y, Kobori A, Miyazaki S, Takei A, Fujii A, Kusa S, Yagishita A, Okubo K, Fujino T, Nozato T, Hikita H, Sato A, Aonuma K. Clinical characteristics of massive air embolism complicating left atrial ablation of atrial fibrillation: lessons from five cases. Europace. 2012;14:204–208.
  9. Kuwahara T, Takahashi A, Kobori A, Miyazaki S, Takahashi Y, Takei A, Nozato T, Hikita H, Sato A, Aonuma K. Safe and effective ablation of atrial fibrillation: importance of esophageal temperature monitoring to avoid periesophageal nerve injury as a complication of pulmonary vein isolation. J Cardiovasc Electrophysiol. 2009;20:1–6.
  10. Kuwahara T, Takahashi A, Kobori A, Miyazaki S, Takahashi Y, Takei A, Nozato T, Hikita H, Sato A, Aonuma K. Response to “Importance of Esophageal Temperature Monitoring Combined With Intracardiac Echocardiography.” 2009;
  11. Kuwahara T, Hamada M, Hiwada K. Direct evidence of impaired cardiac sympathetic innervation in essential hypertensive patients with left ventricular hypertrophy. J Nucl Med. 1998;39:1486–1491.
  12. Kuwahara T, Hamada M, Inoue Y, Aono S, Hiwada K. Warfarin-induced eosinophilic pleurisy. Intern Med. 1995;34:794–796.
  13. Hishikari K, Kimura S, Yamakami Y, Kojima K, Sagawa Y, Otani H, Sugiyama T, Kuwahara T, Hikita H, Takahashi A, Isobe M. The prognostic value of the serum eicosapentaenoic acid to arachidonic acid ratio in relation to clinical outcomes after endovascular therapy in patients with peripheral artery disease caused by femoropopliteal artery lesions. Atherosclerosis. 2015;239:583-588.
  14. Okubo K, Kuwahara T, Takagi K, Takigawa M, Nakajima J, Watari Y, Nakashima E, Yamao K, Fujino T, Tsutsui H, Takahashi A. Rapid Mapping of Right Atrial Tachycardia Using a New Multielectrode Basket Catheter. J Cardiovasc Electrophysiol. 2015;
  15. Okubo K, Kuwahara T, Takagi K, Takigawa M, Nakajima J, Watari Y, Nakashima E, Yamao K, Fujino T, Tsutsui H, Takahashi A. Relation between dabigatran concentration, as assessed using the direct thrombin inhibitor assay, and activated clotting time/activated partial thromboplastin time in patients with atrial fibrillation. Am J Cardiol. 2015;115:1696–1699.
  16. Takigawa M, Kuwahara T, Okubo K, Takahashi A. Sudden manifestation of sinus arrest nine months after catheter ablation treatment for persistent atrial fibrillation. J Arrhythmia. 2015;31:238-239.
  17. Takigawa M, Kuwahara T, Takahashi A, Okubo K, Takahashi Y, Nakashima E, Yamao K, Watari Y, Nakajima J, Takagi K, Fujino T, Kimura S, Hikita H, Hirao K, Isobe M. Simultaneous isolation of superior and inferior pulmonary veins on both the left and right sides could yield better outcomes in patients with paroxysmal atrial fibrillation. Europace. 2015;17:732–740.
  18. Takigawa M, Takahashi A, Kuwahara T, Hirao K, Isobe M. Catheter ablation of atrial fibrillation and thromboembolic risk – reply. Circ J Off J Jpn Circ Soc. 2015;79:445.
  19. Takigawa M, Takahashi A, Kuwahara T, Okubo K, Takahashi Y, Nakashima E, Watari Y, Yamao K, Nakajima J, Takagi K, Kimura S, Hikita H, Hirao K, Isobe M. Impact of Non-Pulmonary Vein Foci on the Outcome of the Second Session of Catheter Ablation for Paroxysmal Atrial Fibrillation. J Cardiovasc Electrophysiol. 2015;26:739–746.
  20. Hikita H, Kuroda S, Oosaka Y, Kawaguchi N, Nakashima E, Sugiyama T, Akiyama D, Kamiishi T, Kimura S, Takahashi Y, Kuwahara T, Sato A, Takahashi A, Isobe M. Response to the letter to the editor “Can statins alter coronary plaque morphology assessed by intravascular ultrasound?” Angiology. 2014;65:552.
  21. Hishikari K, Kuwahara T, Takahashi A, Isobe M. Severe coronary artery spasm during radiofrequency ablation for atrial fibrillation. Int J Cardiol. 2014;172:e513-515.
  22. Miyazaki S, Takigawa M, Kusa S, Kuwahara T, Taniguchi H, Okubo K, Nakamura H, Hachiya H, Hirao K, Takahashi A, Iesaka Y. Role of arrhythmogenic superior vena cava on atrial fibrillation. J Cardiovasc Electrophysiol. 2014;25:380–386.
  23. Miyazaki S, Takigawa M, Taniguchi H, Kuwahara T, Kusa S, Okubo K, Nakamura H, Hachiya H, Hirao K, Takahashi A, Iesaka Y. Prevalence of atrial flutter in patients with and without arrhythmogenic superior vena cava during pulmonary vein isolation. Int J Cardiol. 2014;172:e157–158.
  24. Takigawa M, Takahashi A, Kuwahara T, Okubo K, Takahashi Y, Watari Y, Takagi K, Fujino T, Kimura S, Hikita H, Tomita M, Hirao K, Isobe M. Long-term follow-up after catheter ablation of paroxysmal atrial fibrillation: the incidence of recurrence and progression of atrial fibrillation. Circ Arrhythm Electrophysiol. 2014;7:267-273.
  25. Takigawa M, Takahashi A, Kuwahara T, Takahashi Y, Okubo K, Nakashima E, Watari Y, Nakajima J, Takagi K, Yamao K, Fujino T, Sugiyama T, Kimura S, Hikita H, Irioka T, Hirao K, Isobe M. Late-phase thromboembolism after catheter ablation for paroxysmal atrial fibrillation. Circ J. 2014;78:2394–2401.
  26. Takigawa M, Takahashi A, Kuwahara T, Okubo K, Takahashi Y, Watari Y, Takagi K, Fujino T, Kimura S, Hikita H, Tomita M, Hirao K, Isobe M. Long-term follow-up after catheter ablation of paroxysmal atrial fibrillation: the incidence of recurrence and progression of atrial fibrillation. Circ Arrhythm Electrophysiol. 2014;7:267–273.
  27. Fujino T, Takahashi A, Kuwahara T, Takahashi Y, Okubo K, Takigawa M, Ikeda T. Assessment of clinical factors associated with a successful catheter ablation outcome in younger patients with atrial fibrillation. J Cardiol. 2013;
  28. Hikita H, Kuroda S, Oosaka Y, Kawaguchi N, Nakashima E, Sugiyama T, Akiyama D, Kamiishi T, Kimura S, Takahashi Y, Kuwahara T, Sato A, Takahashi A, Isobe M. Impact of statin use before the onset of acute myocardial infarction on coronary plaque morphology of the culprit lesion. Angiology. 2013;64:375-378.
  29. Hikita H, Shigeta T, Kojima K, Oosaka Y, Hishikari K, Kawaguc hi N, Nakashima E, Sugiyama T, Akiyama D, Kamiishi T, Kimura S, Takahashi Y, Kuwahara T, Sato A, Takahashi A, Isobe M. Lipoprotein(a) is an important factor to determine coronary artery plaque morphology in patients with acute myocardial infarction. Coron Artery Dis. 2013;24:381-385.
  30. Takigawa M, Kuwahara T, Takahashi A, Kobori A, Takahashi Y, Okubo K, Watari Y, Sugiyama T, Kimura S, Takagi K, Hikita H, Hirao K, Isobe M. The impact of haemodialysis on the outcomes of catheter ablation in patients with paroxysmal atrial fibrillation. Eur Eur Pacing Arrhythm Card Electrophysiol J Work Groups Card Pacing Arrhythm Card Cell Electrophysiol Eur Soc Cardiol. 2013;
  31. Takigawa M, Kuwahara T, Takahashi A, Watari Y, Okubo K, Takahashi Y, Takagi K, Kuroda S, Osaka Y, Kawaguchi N, Yamao K, Nakashima E, Sugiyama T, Akiyama D, Kamiishi T, Kimura S, Hikita H, Hirao K, Isobe M. Differences in catheter ablation of paroxysmal atrial fibrillation between males and females. Int J Cardiol. 2013;168:1984-1991.
  32. Miyazaki S, Kobori A, Komatsu Y, Kuwahara T, Uchiyama T, Kusa S, Taniguchi H, Hachiya H, Hirao K, Isobe M, Takahashi A, Iesaka Y. Clinical implication of adenosine test at repeat atrial fibrillation ablation procedure: the importance of detecting dormant thoracic vein conduction. Circ Arrhythm Electrophysiol. 2012;5:1117–1123.
  33. Miyazaki S, Kuwahara T, Takahashi A. Dormant conduction between contiguous pulmonary veins after pulmonary vein antrum isolation. J Cardiovasc Electrophysiol. 2012;23:105.
  34. Miyazaki S, Kuwahara T, Takahashi A. Confined driver of atrial fibrillation in the superior vena cava. J Cardiovasc Electrophysiol. 2012;23:440.
  35. Miyazaki S, Kuwahara T, Takahashi A. Impact of the preprocedural frequency of paroxysmal atrial fibrillation on the clinical outcome after catheter ablation. PACE. 2012;35:1236–1241.
  36. Miyazaki S, Shah AJ, Kobori A, Kuwahara T, Takahashi A. How to approach reentrant atrial tachycardia after atrial fibrillation ablation. Circ Arrhythm Electrophysiol. 2012;5:e1–7.
  37. Miyazaki S, Kuwahara T, Kobori A, Takahashi A. Atrial fibrillation resistant to electrical cardioversion. Int J Cardiol. 2011;151:e80–81.
  38. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A, Isobe M, Takahashi A. Impact of Adenosine-Provoked Acute Dormant Pulmonary Vein Conduction on Recurrence of Atrial Fibrillation. J Cardiovasc Electrophysiol [Internet]. 2011
  39. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A, Isobe M, Takahashi A. Long-term clinical outcome of extensive pulmonary vein isolation-based catheter ablation therapy in patients with paroxysmal and persistent atrial fibrillation. Heart Br Card Soc. 2011;97:668–673.
  40. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A, Isobe M, Takahashi A. Preprocedural predictors of atrial fibrillation recurrence following pulmonary vein antrum isolation in patients with paroxysmal atrial fibrillation: long-term follow-up results. J Cardiovasc Electrophysiol. 2011;22:621–625.
  41. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A, Isobe M, Takahashi A. Prevalence, electrophysiological properties, and clinical implications of dissociated pulmonary vein activity following pulmonary vein antrum isolation. Am J Cardiol. 2011;108:1147–1154.
  42. Takahashi Y, Takahashi A, Kuwahara T, Okubo K, Fujino T, Takagi K, Nakashima E, Kamiishi T, Hikita H, Hirao K, Isobe M. Renal function after catheter ablation of atrial fibrillation. Circulation. 2011;124:2380–2387.
  43. Yagishita A, Takahashi Y, Takahashi A, Fujii A, Kusa S, Fujino T, Nozato T, Kuwahara T, Hirao K, Isobe M. Incidence of late thromboembolic events after catheter ablation of atrial fibrillation. Circ J Off J Jpn Circ Soc. 2011;75:2343–2349.
  44. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A, Isobe M, Takahashi A. Catheter ablation of atrial fibrillation in patients with valvular heart disease: long-term follow-up results. J Cardiovasc Electrophysiol. 2010;21:1193–1198.
  45. Sato A, Nozato T, Hikita H, Miyazaki S, Takahashi Y, Kuwahara T, Takahashi A, Hiroe M, Aonuma K. Incremental value of combining 64-slice computed tomography angiography with stress nuclear myocardial perfusion imaging to improve noninvasive detection of coronary artery disease. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol. 2010;17:19–26.
  46. Sato A, Ohigashi H, Nozato T, Hikita H, Tamura M, Miyazaki S, Takahashi Y, Kuwahara T, Takahashi A, Hiroe M, Aonuma K. Coronary artery spatial distribution, morphology, and composition of nonculprit coronary plaques by 64-slice computed tomographic angiography in patients with acute myocardial infarction. Am J Cardiol. 2010;105:930–935.
  47. Takahashi Y, Takahashi A, Kuwahara T, Fujino T, Okubo K, Kusa S, Fujii A, Yagishita A, Miyazaki S, Nozato T, Hikita H, Hirao K, Isobe M. Clinical characteristics of patients with persistent atrial fibrillation successfully treated by left atrial ablation. Circ Arrhythm Electrophysiol. 2010;3:465–471.
  48. Hikita H, Sato A, Nozato T, Kawashima T, Takahashi Y, Kuwahara T, Takahashi A. Low coronary flow velocity and shear stress predict restenosis after sirolimus-eluting stent implantation. Scand Cardiovasc J SCJ. 2009;43:298-303.
  49. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A, Isobe M, Takahashi A. Pharmacological cardioversion preceding left atrial ablation: bepridil predicts the clinical outcome following ablation in patients with persistent atrial fibrillation. Europace. 2009;11:1620–1623.
  50. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A, Takahashi A, Isobe M. Adenosine triphosphate exposes dormant pulmonary vein conduction responsible for recurrent atrial tachyarrhythmias: importance of evaluating the dormant conduction during the re-do ablation procedure. Circ J. 2009;73:1160–1162.
  51. Takahashi A, Kuwahara T, Takahashi Y. Complications in the catheter ablation of atrial fibrillation: incidence and management. Circ J Off J Jpn Circ Soc. 2009;73:221-226.
  52. Takahashi Y, Takahashi A, Miyazaki S, Kuwahara T, Takei A, Fujino T, Fujii A, Kusa S, Yagishita A, Nozato T, Hikita H, Sato A, Hirao K, Isobe M. Electrophysiological characteristics of localized reentrant atrial tachycardia occurring after catheter ablation of long-lasting persistent atrial fibrillation. J Cardiovasc Electrophysiol. 2009;20:623–629.
  53. Miyazaki S, Kuwahara T, Takahashi A, Kobori A, Takahashi Y, Nozato T, Hikita H, Sato A, Aonuma K, Hirao K, Isobe M. Effect of left atrial ablation on the quality of life in patients with atrial fibrillation. Circ J. 2008;72:582–587.
  54. Miyazaki S, Takahashi A, Kuwahara T, Kobori A, Yokoyama Y, Nozato T, Sato A, Aonuma K, Hirao K, Isobe M. Randomized comparison of the continuous vs point-by-point radiofrequency ablation of the cavotricuspid isthmus for atrial flutter. Circ J Off J Jpn Circ Soc. 2007;71:1922–1926.
  55. Kodama-Takahashi K, Suzuki J, Watanabe A, Ohtsuka T, Hashida H, Ikeda S, Kuwahara T, Hara Y, Shigematsu Y, Hamada M, Hiwada K. Ischemia in the territory of the first major septal perforator branch anomalously originating from the first diagonal branch leads to a transient leftward shift of the QRS axis in the frontal plane: a case report. Circ J Off J Jpn Circ Soc. 2003;67:885–888.
  56. Hara Y, Hamada M, Shigematsu Y, Suzuki M, Kodama K, Kuwahara T, Hashida H, Ikeda S, Ohtsuka T, Hiasa G, Hiwada K. Effect of beta-blocker on left ventricular function and natriuretic peptides in patients with chronic heart failure treated with angiotensin-converting enzyme inhibitor. Jpn Circ J. 2000;64:365–369.
  57. vHiasa G, Hamada M, Kodama K, Watanabe S, Ohtsuka T, Ikeda S, Hashida H, Kuwahara T, Hara Y, Shigematsu Y, Hiwada K. Apical hypertrophic cardiomyopathy associated with life-threatening paroxysmal atrial flutter with a slow ventricular response: a case report. Jpn Circ J. 2000;64:225–228.
  58. Kodama K, Hiasa G, Ohtsuka T, Ikeda S, Hashida H, Kuwahara T, Hara Y, Shigematsu Y, Hamada M, Hiwada K. Transient U wave inversion dur ing treadmill exercise testing in patients with left anterior descending coronary artery disease. Angiology. 2000;51:581–589.
  59. Kodama K, Hamada M, Kuwahara T, Nakamura M, Shigematsu Y, Hiwada K, Iwata T, Hoshii Y, Ishihara T. Rest-redistribution thallium-201 myocardial scintigraphic study in cardiac amyloidosis. Int J Card Imaging. 1999;15:371–378.
  60. Hamada M, Kuwahara T, Shigematsu Y, Kodama K, Hara Y, Hashida H, Ikeda S, Ohtsuka T, Nakata S, Hiwada K. Relation between coronary blood flow and left ventricular mass in hypertension: noninvasive quantification of coronary blood flow by thallium-201 myocardial scintigraphy. Hypertens Res Off J Jpn Soc Hypertens. 1998;21:227–234.
  61. Hashida H, Hamada M, Shigematsu Y, Ikeda S, Kuwahara T, Kawakami H, Hara Y, Kodama K, Kohara K, Hiwada K. Beneficial hemodynamic effects of oral prostacyclin (PGI2) analogue, beraprost sodium, on a patient with primary pulmonary hypertension–a case report. Angiology. 1998;49:161–164.
  62. Ohtsuka T, Hamada M, Hara Y, Kuwahara T, Kodama K, Shigematsu Y, Iwata T, Hiwada K. An early systolic sound associated with midventricular obstruction in a patient with hypertrophic cardiomyopathy. Jpn Circ J. 1998;62:385–388.
  63. Ohtsuka T, Hamada M, Kodama K, Ikeda S, Hashida H, Kuwahara T, Hara Y, Shigematsu Y, Hiwada K. Marked attenuation of mitral regurgitation by stent implantation: a patient with unstable angina. J Cardiol. 1998;31 Suppl 1:91–95; discussion 96.
  64. Shigematsu Y, Hamada M, Ohtsuka T, Hashida H, Ikeda S, Kuwahara T, Hara Y, Kodama K, Hiwada K. Left ventricular geometry as an independent predictor for extracardiac target organ damage in essential hypertension. Am J Hypertens. 1998;11:1171–1177.
  65. Hashida H, Hamada M, Ikeda S, Kuwahara T, Okayama H, Hara Y, Kodama K, Shigematsu Y, Kazatani Y, Tomino T, Satoh H, Hiwada K. [Mitral prosthetic valve replaced twice due to repeated prosthetic valve endocarditis: a case report]. J Cardiol. 1997;29 Suppl 2:137–141.
  66. Hamada M, Shigematsu Y, Kobayashi T, Kodama K, Hayashi Y, Hara Y, Okayama H, Kawakami H, Kuwahara T, Ikeda S, Hashida H, Hiwada K. [Familial hypertrophic cardiomyopathy generating a marked left ventricular pressure gradient in an 82-year-old woman]. Nihon Ronen Igakkai Zasshi Jpn J Geriatr. 1996;33:284–292.
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